Helena F. Florindo

Helena Isabel Fialho Florindo Roque Ferreira
Universidade de Lisboa, Lisbon
Principal investigator

Sensitizing pancreatic cancer to immunotherapy with multimodal precision nanomedicines.

• María Jesús Vicent Docón (PL)
  Centro de Investigación Príncipe Felipe, Valencia

• Ronit Satchi-Fainaro
  Sackler Faculty of Medicine Tel Aviv University, Tel Aviv

Helena Florindo is an associate professor with tenure and habilitation at the Farmacy Faculty of Universidade de Lisboa and Group Leader at the at the Research Institute for Medicines (iMed.ULisboa, Universidade de Lisboa). Both nanotechnology and immune-oncology fields have motivated her research, which has been focused on the rational development of novel chemically defined functionalized nanobiomaterials as novel immunotherapies for cancer treatment. She graduated in Pharmaceutical Sciences and concluded her PhD degree in Pharmaceutical Sciences by the University of Lisbon, in collaboration with the University of London. She is a member of the Portuguese Medicines Agency Evaluation Board (INFARMED), and since 2022, she is the President of the Spanish-Portuguese Local Chapter at the Controlled Release Society. (Read the full CV).

Her major topics of research are:

1. Regulation of immunity by targeting dendritic cells (DCs) using nanotechnology-based tools to i) enhance antigen delivery to DC; ii) modulate antigen intracellular processing and presentation pathways; iii) block signaling pathways related to tumor evasion mechanisms.

2. Size-based targeting of lymph node-resident immune cells by nanoparticles to overcome major barriers for vaccine components and immunotherapies.

3. Dissect tumor stromal and immune cell interplay to guide the design of multi-targeting nano-conjugates. It includes the characterization of the interplay immune cells-lymphatic endothelial cells-tumor cells, which knowledge we are using to tailor nano-therapeutic development.

Faculdade de Farmácia
Universidade de Lisboa,
Av Prof Gama Pinto, Edifício F
1649-003, Lisboa, Portugal
Tel.: (+351) 217 946 400 (Ext.14244)

Email: [email protected]
Twitter: @FlorindoLab