Arkaitz Carracedo

Arkaitz Carracedo
Centro de Investigación Cooperativa en Biociencias (CIC bioGUNE), Spain
Eradicating prostate cancer metastasis before clinical manifestation
Project leader

• Christian Frezza
  University of Cambridge, UK

• Mireia Castillo
  Fundação Champalimaud, Portugal

• Jordi Llop
  CIC biomaGUNE, Spain

• Ana Loizaga
  Basurto Hospital, Spain

Our Research project stems from the computational identification of metabòlic genes with prognostic potential. During the grant period, we have discovered that stroma metabolism is a strong predictor of Disease progression. This, in turn, has open the door to a new prognostic biomarker, to histological markers of prostate cancer aggressiveness and has provided fundamental information around the complex bidirectional cross-talk between tumor cells and their surroundings.

Dr. Carracedo is Group Leader of the CIC bioGUNE and IKERBASQUE Research Professor. He is Associate Professor at University of the Basque Country. He did a postdoctoral fellow at the Pier Paolo Pandolfi's laboratory, at the Memorial Sloan-Kettering Cancer Center. Carracedo is a member of the Board of Director of the European Association for Cancer Research and a member of the board of trustees of the AECC (Asociación Española Contra el Cáncer).

https://es.linkedin.com/in/arkaitzcarracedo1979

Cancer cell signalling, oncogenic PI3K-mTOR pathway, resistance to therapy, contribution of cell metabolism to cancer cell biology

• Arruabarrena-Aristorena, A., A. Zabala-Letona and A. Carracedo (2018). "Oil for the cancer engine: The cross-talk between oncogenic signaling and polyamine metabolism." Sci Adv 4(1): eaar2606. 10.1126/sciadv.aar2606.

• Bruzzone, C., A. Loizaga-Iriarte, P. Sanchez-Mosquera, R. Gil-Redondo, I. Astobiza, T. Diercks, A. R. Cortazar, A. Ugalde-Olano, H. Schafer, F. J. Blanco, M. Unda, C. Cannet, M. Spraul, J. M. Mato, N. Embade, A. Carracedo and O. Millet (2020). "(1)H NMR-Based Urine Metabolomics Reveals Signs of Enhanced Carbon and Nitrogen Recycling in Prostate Cancer." J Proteome Res. 10.1021/acs.jproteome.0c00091.

• Carracedo, A., L. C. Cantley and P. P. Pandolfi (2013). "Cancer metabolism: fatty acid oxidation in the limelight." Nat Rev Cancer 13(4): 227-232. 10.1038/nrc3483.

• Houston, S. (2019). "Arkaitz Carracedo: If the scientific question is good, the result will be interesting." J Exp Med 216(11): 2449-2450. 10.1084/jem.20191880.

• Keshet, R., P. Szlosarek, A. Carracedo and A. Erez (2018). "Rewiring urea cycle metabolism in cancer to support anabolism." Nat Rev Cancer 18(10): 634-645. 10.1038/s41568-018-0054-z.

• Valcarcel-Jimenez, L., E. Gaude, V. Torrano, C. Frezza and A. Carracedo (2017). "Mitochondrial Metabolism: Yin and Yang for Tumor Progression." Trends Endocrinol Metab 28(10): 748-757. 10.1016/j.tem.2017.06.004.

• Zabala-Letona, A., A. Arruabarrena-Aristorena, N. Martin-Martin, S. Fernandez-Ruiz, J. D. Sutherland, M. Clasquin, J. Tomas-Cortazar, J. Jimenez, I. Torres, P. Quang, P. Ximenez-Embun, R. Bago, A. Ugalde-Olano, A. Loizaga-Iriarte, I. Lacasa-Viscasillas, M. Unda, V. Torrano, D. Cabrera, S. M. van Liempd, Y. Cendon, E. Castro, S. Murray, A. Revandkar, A. Alimonti, Y. Zhang, A. Barnett, G. Lein, D. Pirman, A. R. Cortazar, L. Arreal, L. Prudkin, I. Astobiza, L. Valcarcel-Jimenez, P. Zuniga-Garcia, I. Fernandez-Dominguez, M. Piva, A. Caro-Maldonado, P. Sanchez-Mosquera, M. Castillo-Martin, V. Serra, N. Beraza, A. Gentilella, G. Thomas, M. Azkargorta, F. Elortza, R. Farras, D. Olmos, A. Efeyan, J. Anguita, J. Munoz, J. M. Falcon-Perez, R. Barrio, T. Macarulla, J. M. Mato, M. L. Martinez-Chantar, C. Cordon-Cardo, A. M. Aransay, K. Marks, J. Baselga, J. Tabernero, P. Nuciforo, B. D. Manning, K. Marjon and A. Carracedo (2017). "mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer." Nature 547(7661): 109-113. 10.1038/nature22964.

Asociación Centro de Investigación Cooperativa en Biociencias
Bizkaia Science and Technology Park bld 801 A
48160 Derio, Bizkaia
Spain
Tel.: +34 944 061 300

https://www.cicbiogune.es/