Elías Campo

Elías Campo
Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Spain
Combating the most common form of leukemia through an in-depth understanding of diverse cases of the disease
Project leader

• Carlos López-Otín
  Universidad de Oviedo (UNIOVI), Spain
  Co-leader

• David Torrents
  Barcelona Supercomputing Center (BSC), Spain
  Co-leader

In the current project we have completed the map of genomic alterations of chronic lymphocytic leukemia by sequencing and reanalyzing the genomes and epigenome of more than 1100 patients. We have identified novel mutated genes, mutations in non-coding regions, structural alterations, de novo reprogrammed regulatory regions and discovered novel transcriptome defined subtypes of the disease with clinical implications. We have also discovered the presence of early diversification of the original tumor clone generating diminutive subclones that remain dormant for many years before expanding massively at different time points of the disease and eventually transforming to a deadly aggressive lymphoma. We have also designed and validated novel bioinformatic tools to facilitate the genomic analysis in research and clinical practice.

Dr. Campo is Professor of Pathology and Senior Consultant at the Hospital Clinic of Barcelona, University of Barcelona and Director of the Institute of Biomedical Research August Pi I Sunyer (IDIBAPS) of Barcelona. He has been member at large of the Executive Committees of the Society of Hematopathology and European Association for Haematopathology in which he served as President (2012-2014). He has also been the Co-director of the Chronic Lymphocytic Leukemia Genome Project in the International Consortium of the Cancer Genome. He is co-editor of 2 books (WHO classification of Hematological neoplasms and Haematopathology) and received the National Research Award Gregorio Marañón in the area of Medicine in 2020. He was elected member of the USA National Academy of Medicine in 2018.

• https://es.linkedin.com/in/elias-campo-a2b14920a

• https://orcid.org/0000-0001-9850-9793

His research is focused on the pathological characterization of lymphoid neoplasms and the study of molecular mechanisms involved in the development and progression of these tumours with particular interest in the translation of this knowledge into the clinical practice.

• Nadeu F, Royo R, Massoni-Badosa R et al Early seeding of future Richter transformation in chronic lymphocytic leukemia. Nat Medicine 2022 (In press).

• Binyamin A. Knisbacher BA, Lin Z, Hahn CK, Nadeu F et al Molecular map of chronic lymphocytic leukemia and its impact on outcome. Nat Genetics 2022 (In press).

• Nadeu F, Royo R, Clot G et al. IGLV3-21R110 identifies an aggressive biological subtype of chronic lymphocytic leukemia with intermediate epigenetics. Blood 2021;137:2935-2946. doi: 10.1182/blood.2020008311.

• Duran-Ferrer M, Clot G, Nadeu F, et al. The proliferative history shapes the DNA methylome of B-cell tumors and predicts clinical outcome. Nat Cancer. 2020 Nov;1(11):1066-1081. doi: 10.1038/s43018-020-00131-2.

• Nadeu F, Mas-de-Les-Valls R, Navarro A,et al IgCaller for reconstructing immunoglobulin gene rearrangements and oncogenic translocations from whole-genome sequencing in lymphoid neoplasms. Nature Commun. 11: 3390 (2020).

• Nadeu F, Diaz-Navarro A, Delgado J, Puente XS, Campo E. Genomic and Epigenomic Alterations in Chronic Lymphocytic Leukemia. Annu Rev Pathol 2020;15:149-177. doi: 10.1146/annurev-pathmechdis-012419-032810.

• Shuai S, Suzuki H, Diaz-Navarro A, Nadeu F et al The U1 spliceosomal RNA is recurrently mutated in multiple cancers. Nature. 2019;574:712-716. doi: 10.1038/s41586-019-1651-z.

• Beekman R, Chapaprieta V, Russiñol N, et al The reference epigenome and regulatory chromatin landscape of chronic lymphocytic leukemia. Nat Med. 2018 Jun;24(6):868-880. doi: 10.1038/s41591-018-0028-4.

• Puente XS, Beà S, Valdés-Mas R, et al Non-coding recurrent mutations in chronic lymphocytic leukaemia. Nature 2015;526:519-24. doi: 10.1038/nature14666.

IDIBAPS
C/ Rosselló, 149-153
08036 Barcelona
Spain
Tel.: +34 93 227 57 07

https://www.clinicbarcelona.org/ca/idibaps