Agostinho Carvalho

Agostinho Carvalho
Universidade do Minho (UM), Portugal
A Transdisciplinary Approach to the Identification of Personalized Biomarkers and Therapeutic Targets for Chronic Pulmonary Aspergillosis
Project awarded in collaboration with the Fundação para a Ciência e a Tecnologia
Project leader

• Coral Barbas
  Fundación Universitaria San Pablo (CEU), Spain
  Co-Leader

• Georgios Chamilos
  University of Crete, Greece

• Alexander Mosig
  Jena University Hospital, Germany

• Frank L. van de Veerdonk
  Stichting Katholieke Universiteit (SKU), Holland

The project involves a systems medicine approach to identify novel disease mechanisms, biomarkers, and therapeutic targets for personalized medical interventions in patients at-risk of fungal infection. We have identified interindividual genetic variation that modulates fungal-sensing transcriptional responses and that controls the efficiency of anti-fungal immunity. The role of these genetic variants during fungal infection is currently being profiled in advanced lung-on-a-chip model systems and a clinical study is being developed to identify their association with fungal disease. We expect these results to contribute significantly to clinical practice in pulmonary medicine by opening new horizons and laying the foundations for personalized approaches based on individual patient profiles.

Dr. Carvalho is a Principal Investigator of the Life and Health Sciences Research Institute (ICVS) of the School of Medicine of the University of Minho. He joined the ICVS in 2014 after becoming an Assistant Researcher (FCT Investigator). He previously was an Assistant Researcher at the Department of Experimental Medicine of the University of Perugia, Italy, and completed postdoctoral studies on the genetic basis of susceptibility to fungal infection at the ICVS, and the University of Perugia.

https://orcid.org/0000-0001-8935-8030

Dissection of the regulatory effects of interindividual genetic variation on molecular and cellular processes of immunity, and the identification of novel prognostic, diagnostic and therapeutic targets for the development of personalised medical interventions in patients at-risk of fungal infection. These aims are being addressed by a multidisciplinary team that combines basic scientists and clinical experts, and that resorts to advanced cellular and animal models of disease and human patients enrolled in national and international consortia.

• ResearchGate

• (FF1C-FC2E-2E27) | CIÊNCIAVITAE

Life and Health Sciences Research Institute (ICVS)
Universidade do Minho
Campus de Gualtar
4710-057 Braga
Portugal
Tel.: +351 253 604 811

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