Predictive biomarkers for the endovascular treatment of acute ischemic stroke

Alicia Martínez Piñeiro

Instituto de Investigación Germans Trias i Pujol (IGTP), Spain

Stroke is a major cause of adult disability and mortality. In the last decade, Mechanical Thrombectomy (MT) was a major advance in the treatment of acute ischemic stroke. Nonetheless, successful revascularization of large vessel occlusions does not always lead to good clinical outcome. The rate of significant functional disability after an acute ischemic stroke still ranges from 40 % to 67 %. N20 response from Somatosensory Evoked Potentials (SEPs), as a surrogate of cerebral blood flow, could predict which patients will respond satisfactorily after MT.

Thus, the project aims to develop an automatic computational method for N20 recording and measurement. This software could be implemented in a pocket and portable device which allows SEPs recording by healthcare staff (pre- and intrahospitalary) and provide early data about N20 value, speeding up streamline decision-making and determining a priori who should be directly transferred to a comprehensive stroke center or even to the angiosuite for MT and in whom it will be futile.