Application to calculate the outcome for patients with subarachnoid haemorrhage

Marcin Wojciech Balcerzyk

Centro Nacional de Aceleradores, Spain

Subarachnoid Haemorrhage (SAH) consists of a spill of blood in the space between the meningeal structures that surround the brain. Its incidence is estimated at between 4-28/100,000 inhabitants, often followed by vasospasm and/or delayed cerebral ischemia (Vs/DCI) 3-14 days after the primary event. Mortality is 28-55 % and morbidity 90 %. Precision in the classification of the SAH is very dependent on the quality of Computed Tomography (CT) and the ability of the medical professional who interprets it.

A patent-pending method has been developed for calculating the probabilities of Vs/DCI and death of the patient based on CT head scan in the emergency room. With basic clinical data of Hunt-Hess and World Federation of Neurosurgical Societies (WFNS) neurological evaluation of the patient allows obtaining the probabilities within 1-5 minutes from uploading the CT image and clinical data to a web app.

As far as the researchers know, no such automatic service is currently available on the market. There are two software systems which help evaluation of another brain pathology, stroke: iSchemaView RAPID, Brainomix e-ASPECT and Viz LVO of Viz.ai. The patent-pending method can be developed as independent Software-as-a-Service (SaaS) or be incorporated into CT acquisition computers.

The project aims to bring this SaaS to market by executing all necessary actions for it to be a medical device including but not limited to freedom-to-operate, CE 0123 & Food and Drug Administration (FDA) certification and initiation of incorporation as a company. The project also intends to extend it to Intracerebral Haemorrhage (IH) and calculation of mRS and Glasgow Outcome Scale (GOS) outcome with Artificial Intelligence methods using about 200 SAH and 800 IH 3D CT images to train with.