The reason for hereditary arrhythmias that cause sudden death in young people

Silvia G. Priori

  • PROJECT LEADER

    Silvia G. Priori

  • HOST ORGANIZATION,
    COUNTRY

    Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III - CNIC, Spain

  • DESCRIPTION

    Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a hereditary arrhythmia that can cause syncope, cardiac arrest and sudden death in children and young people with no previous heart disease. Current treatments offer only partial, limited protection against heart failure.

    One of the genetic variants of this disease, CPVT5, is caused by the reduction of a protein (triadin) that determines structural abnormalities in heart cells, as occurs in other myocardial infarctions.

    The project investigates the underlying molecular mechanisms in this type of arrhythmia to deepen our knowledge and find new treatments, which may also be applied to other types of heart failure.

  • PROJECT TITLE

    Loss of Triadin impairs cardiac proteostasis disclosing pathophysiological complexity in Catecholaminergic Polymorphic Ventricular Tachycardia Type 5

  • BUDGET

    €496,100