The tau protein against neurodegenerative diseases

José Antonio del Río Fernández

Institut de Bioenginyeria de Catalunya (IBEC), Spain

The tau protein, associated with various neurodegenerative processes called tauopathies, is present in numerous diseases such as Alzheimer’s disease. But these tauopathies may vary depending on the specific characteristics of the protein and what type of cell they are found in. All these factors manifest themselves with different clinical symptoms depending on the disease.

In recent years, the tau protein has been shown to be an alternative therapeutic target for treating cognitive disabilities in some diseases, after strategies aimed at treating beta-amyloid accumulations have not fully worked in Alzheimer’s disease.

The project aims to dissect the molecular mechanisms involved in the appearance and propagation of the tau protein in brain cells, both in neurons and glial cells, in order to design new therapies to stop its propagation in different tauopathies.

• Isidro Ferrer Abizanda, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Spain

• Ernest Giralt Lledó, Institut de Recerca Biomèdica (IRB Barcelona), Spain

• Jordi Soriano Fradera, Universitat de Barcelona and Institute of Complex Systems (UBICS), Spain

Modulation of Tau seeding and pathology in tauopathies by BBB-nanocarriers, epitope selective vaccination and ectoPrP Tau receptors bodies

€763,002