Innovative liquid-based ECMO system

Thomas Hermans

Fundación IMDEA Nanociencia, Madrid, Spain

Extracorporeal Membrane Oxygenation (ECMO) is a technique that takes over the function of the heart and lungs, but it has significant risks, including bleeding and blood clots. These complications arise because the machine forces blood through pumps and tiny tubes, which can damage blood cells. In order to overcome that, the researchers are developing a new "liquid-walled" ECMO system that replaces solid parts with a soft magnetic fluid, which gently supports and moves the blood without causing harm.

This innovative approach requires being tested in piglets, with the goal of making it safe for human use in the future. By closely monitoring how blood behaves in this liquid environment, the aim is to create a safer ECMO system that could improve survival rates.

The current state of ECMO technology has several limitations, including high mechanical forces on blood components, the presence of foreign solid surfaces, and the use of continuous flow pumps. These factors necessitate the use of anticoagulants, which can lead to bleeding and other complications. With this new system those issues would be solved and it would provide a gentle, non-damaging environment for blood flow.

Preliminary data from a prototype has demonstrated minimal damage to blood cells and stability of the magnetic fluid at high shear rates, meaning that the project has the potential to significantly improve ECMO technology, making it safer and more effective for patients. By reducing complications and improving outcomes, this innovative approach could save many lives and transform the field of critical care.

• Maria José Santiago Lozano, Fundación para la Investigación Biomédica del Hospital Gregorio Marañón, Madrid, Spain

Liquid-walled circuits for anticoagulant-free Extra-corporeal Membrane Oxygenation

€999.816,40