Innovative strategies to tackle antimicrobial resistance by understanding resistance genes

José Antonio Escudero García-Calderón

Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain

The pressing issue of antimicrobial resistance (AMR) is growing every day, it poses a significant threat to global health, and we are in urgent need of overcoming the issue. This project aims to uncover the hidden functions of resistance genes that go beyond their known role in fighting antibiotics. These genes can interfere with other biological processes, impacting the success of the resistance gene and the bacteria's overall fitness. The project will explore these hidden functions and understand their impact on bacterial physiology.

The research team will employ advanced techniques to study the interactions between resistance genes and the host's cellular processes. They will analyze how these genes affect the host's gene expression and identify the proteins involved in these interactions. This comprehensive approach will provide insights into the secondary functions of resistance genes and their role in the evolution of AMR.

The project is expected to reveal new targets for combating AMR by identifying interactions that can be exploited for future treatments. By understanding the hidden roles of resistance genes, the research will contribute to developing innovative strategies to fight AMR and improve public health.

Discovering moonlighting activities of antimicrobial resistance genes

€499.570,00