Prevent cardiovascular disease

José Antonio Enríquez

Centro Nacional de Investigaciones Cardiovasculares Carlos III - CNIC, Madrid, Spain

Cardiovascular diseases, the world's leading cause of death, account for more than 17 million premature deaths each year. Although this is a very broad term that encompasses a variety of diseases with different pathophysiological mechanisms, most have in common that they involve inflammation, which aggravates the disease. Reducing cardiac inflammation would therefore represent a significant medical advance in the treatment of these pathologies.

In previous work, the project team discovered that FGR kinase, an enzyme that plays a crucial role in regulating cellular physiological processes, is activated during cellular stress. When activated in the mitochondria, it promotes inflammation. The amount of FGR has been found to be increased in cardiovascular diseases such as arrhythmogenic dysplasia.

In this project, the team will study how activation of this enzyme affects heart function and whether its inhibition is protective against heart disease.

Inflammation in Cardiovascular diseases: Mitochondrial Fgr Kinase as a therapeutic target

€498,000.00