Combating antimicrobial resistance

João Morais Cabral

i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Portugal

The rise in antimicrobial resistance, a natural process in which microorganisms develop resistance to the drugs used to treat them, is a serious problem and one of the greatest threats to global health. Combating antimicrobial resistance involves preventing the misuse and abuse of antibiotics and finding new approaches to combat bacterial infections, either by discovering new drugs or by finding ways to increase bacterial sensitivity to existing antibiotics.

This project focuses on finding and characterising fundamental biological processes in bacteria that are crucial for their viability. Specifically, the researchers will study bacterial proteins to determine whether they may be viable antibacterial targets that can be further explored to develop future clinical applications.

Using small-molecule inhibitors to explore the unique properties of the bacterial K+ machinery and its potential as an antibacterial target

€498,999