Personalised therapy against a rare childhood cancer

Luciano Di Croce

  • PROJECT LEADER

    Luciano Di Croce

  • HOST ORGANIZATION, COUNTRY

    Centre de Regulació Genòmica, Spain

  • DESCRIPTION

    Brain stem glioma is a rare, fast-growing tumour that localises in the cerebral structure that connects the brain to the rest of the body. The tumour particularly affects children, there is currently no treatment and its prognosis is bad.

    The tumour is made up of very different cells that vary from one patient to another and may even change during the course of the illness. This makes finding an effective treatment difficult.

    Until now, research into this tumour has been based on studies at the level of individual cells. However, this project proposes 3D multicellular reconstruction of the tumour using personalised models of the patient in mice ((PDX-patient derived xenograft). These models would enable individualised treatments to be tested for this type of cancer.

  • CONSORTIUM
    (PRINCIPAL INVESTIGATOR, ORGANIZATION, COUNTRY)

    Jaume Mora, Fundació Sant Joan de Déu, España

  • PROJECT TITLE

    Virtual patient derived xenografts for tumor treatment (vPDX)

  • BUDGET

    990.160 €