Bacterial engineering for the treatment of pneumonia

Luis Serrano Pubul

  • PROJECT LEADER

    Luis Serrano Pubul

  • HOST ORGANIZATION,
    COUNTRY

    Fundació Centre de Regulació Genòmica (CRG), Spain

  • DESCRIPTION

    In Europe, infectious diseases are the second leading cause of death. Among them, bacterial pneumonias are the most common. In bacterial infections, the creation of a biofilm allows adhesion to surrounding tissues and protects bacteria against the immune response as well as promoting resistance to antibiotics. The risk is greater in patients with chronic respiratory diseases and in patients requiring hospital admission, endotracheal intubation or assisted ventilation.

    The project seeks new therapies for this type of pneumonia based on the design of genetically modified bacteria to administer agents that dissolve the biofilm, kill pathogenic bacteria and reduce inflammation locally. The aim is to determine the efficacy and safety of these cellular compounds in a preliminary animal model.

  • CONSORTIUM
    (PRINCIPAL INVESTIGATOR,
    ORGANIZATION, COUNTRY)

    Antoni Torres, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Spain

  • PROJECT TITLE

    Bacterial lung chassis for treating human lung infectious diseases

  • BUDGET

    €999,528