Drugs against vascular malformations

Mariona Graupera

Institut de Recerca contra la Leucèmia Josep Carreras (IJC), Spain

Vascular malformations are a heterogeneous group of diseases caused by an alteration of the growth or formation of blood vessels that produce functional alterations in the tissues where they are found. There is no treatment for these pathologies, which mainly affect children and young adults.

These pathologies are painful and cause bleeding, infections and can even damage organs. There are two types of malformations: those that affect the veins and those that damage the arteries, each caused by a different mutation.

Current treatments are very invasive. For this reason, the project proposes to study the molecular mechanisms underlying these neglected diseases and to find new therapies for vascular malformations.

• Rui Miguel dos Santos Benedito, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Spain

• Eulàlia Baselga Torres, Fundació Privada Hospital de la Santa Creu i Sant Pau, Spain

• Jaume Mora Graupera, Fundació Sant Joan de Déu, Spain

Mapping the pathogenesis of vascular malformations

€755,018