An innovative therapy for brain tumours in children

Marta M Alonso

Fundación para la Investigación Médica Aplicada (Cima Universidad de Navarra), Navarre, Spain

This project is focused on developing improved treatments for Diffuse Midline Gliomas (DMGs), the most aggressive form of brain tumours in children. These tumours currently have extremely limited treatment options, none of which are curative, resulting in very low chances of long-term survival. Existing medical approaches typically offer only temporary relief and may adversely affect a child’s overall development and quality of life.

The proposed solution involves a specially engineered virus designed to selectively destroy the cancer cells responsible for these tumours while sparing healthy brain tissue. In addition to directly attacking tumour cells, this therapy also stimulates the child’s immune system to better recognize and fight the cancer. Early laboratory studies have shown promising results, suggesting that the therapy may slow or even halt the progression of DMGs.

The primary goal of this project is to prepare the therapy for clinical trials in children with DMGs. Researchers will conduct further preclinical studies to assess safety and efficacy. They will also develop a strategy for manufacturing and delivering the therapy to hospitals, ensuring that it reaches the children who need it most.

If successful, this project could lead to a safer, more effective treatment for children with DMGs. Furthermore, the same therapeutic approach holds promise for other difficult-to-treat solid tumors, potentially opening new avenues for innovative cancer therapies and improved outcomes for many patients and their families.

Overcoming resistance to virotherapy for pediatric brain tumors

Stage 2